Hepatoprotective Effects of Ethanol Leaf Extracts of Andrographis paniculata and Tapinanthus bangwensis on Male Albino Wistar Rats
Keywords:
Hepatoprotective, Andrographis Paniculata, Tapinanthus Bangwensis, Albino Wistar Rats, Liver EnzymesAbstract
Assessment of hepatoprotective properties of ethanol leaf extracts of Andrographis paniculata and Tapinanthus baugwensis on male albino Wistar rats weighing 74 – 186 g was conducted for one month. Twenty-five animals were randomly assigned to five groups of five rats each. Groups 1 and 2 were treated orally with 200 mg/kg and 300 mg/kg combined leaf extracts of A. paniculata and T. bangwensis, respectively, at a 50:50 dosage ratio. Groups 3 and 4 were treated with 200 mg/kg each of A. paniculata and T. bangwensis, respectively. Group 5 was not treated with either of the plant extracts and served as a control. The animals were allowed free access to commercial rat mash and water throughout treatment. At the end of treatment, serum AST, ALT, and ALP showed no significant difference (p>0.05) compared to the control. No significant difference (p>0.05) was also observed among the treatment groups. Serum total protein revealed no significant difference (p>0.05) in the treatment groups when compared to the control, and there was no significant difference (p>0.05) among the treatment groups. Serum albumin showed a significant decrease (p<0.05) in group 3 when compared to the control. Total bilirubin and direct total bilirubin levels showed a significant decrease (p<0.05) in the control group when compared to the treatment groups, but no significant difference (p>0.05) was recorded among the treatment groups. No significant difference (p>0.05) was also observed in serum indirect bilirubin levels in the treatment groups when compared to the control and when compared among the treatment groups. Therefore, these results implied that single and combined leaf extracts of A. paniculata and T. bangwensis exhibited hepatoprotective properties as they did not cause any adverse effect on the liver function parameter.
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