In Vitro Antimicrobial, Antidiabetic, Antioxidant, and Antiulcerogenic Properties of Methanolic and Aqueous Leaf Extracts of Thaumatococcus daniellii
Keywords:
Thaumatococcus daniellii, Antidiabetic, Antioxidant, Antiulcerogenic, AntimicrobialsAbstract
The phytochemical composition, antimicrobial, antidiabetic, antioxidant and antiulcerogenic properties of leaf extracts of Thaumatococcus daniellii were investigated. The invitro effects of methanolic and aqueous leaf extracts of T. danielii at various concentrations (7.8125-1000 μg/mL) on the activities of α-amylase and α-glucosidase were used to evaluate its anti-diabetic potential. The phytochemical screening of the methanolic and aqueous leaf extracts of T. danielii confirmed the presence of saponins, phenol, alkaloids and tannins. The methanoilc leaf extract of T. danielii showed inhibitory activity against Klebsiella pneumoniae at 50 mg/ml and 100 mg/ml concentrations. The methanolic and aqueous leaf extracts of T. danielii inhibited α-amylase, α-glucosidase and aldose reductase enzymes in a concentration-dependent manner. The standard oxidant as well as methanolic and aqueous leaf extracts of T. danielii showed increased inhibitory activities of hydrogen peroxide, nitric oxide and hydroxyl radical with increasing concentrations. The total antioxidant activity of the standard antioxidant (Butylated Hydroxytoluene) is higher than those of methanolic and aqueous leaf extracts of T. danielii. The invitro assays indicate that methanolic and aqueous leaf extracts of T. danielii is a significant source of natural antidiabetic agent, which might be helpful in preventing and treatment of diabetes. The aqueous and methanolic leaf extracts of T. danielii also showed potent H+/K+-ATPase inhibitory property; hence, they may be used as potential antiulcerogens.
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