Mathematical Modeling and Integrated Optimal Control of HCV–Typhoid Coinfection in Developing Nations
DOI:
https://doi.org/10.63561/jmns.v3i1.1161Keywords:
HCV, Typhoid Fever, Coinfection, Optimal Control, SanitationAbstract
Hepatitis C virus (HCV) and Typhoid fever present low-level endemic status in developing countries. Unregulated use of medical practices, inadequate sanitation, and poor health infrastructure aggravate the situation. Past studies have concentrated on the transmission of the diseases and employed basic modelling. However, the need for integrated control strategies has been largely ignored. The present study employs a deterministic mathematical model to examine the impact of integrated control strategies (Typhoid intervention, Typhoid and HCV treatment, sanitation, and HCV screening) on reducing the burden of Typhoid and HCV coinfection in a high-risk population. Optimal control theory is used to model the implementation of the strategies for a period of 400 days. The study findings indicate that simultaneous implementation of the strategies Multiple Health Interventions for HCV and Typhoid treatments, coupled with improved control of environmental sanitation, and Typhoid and HCV screening, would be most effective in addressing the dual burden of Typhoid and HCV coinfection in developing countries such as Nigeria.
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