Multifaceted Investigations of Mixed-Ligand Metal(II) Complexes: Synthesis, Characterization, DFT, and Biological Studies
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Abstract
The study described the synthesis, characterization, DFT and biological studies of Mixed-ligand divalent complexes ([M(L1)(L2)]nH2O)(M= Cu2+, Fe2+ and Mn2+, L1=SBL1, L2=SBL2, n=0,I,2,3,4) containing 3-(E)-4-(((2-hydroxynaphthalen-1-yl)methylene)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one [SBL1] and (E)-1-(((6-nitrobenzo[d]thiazol-2-yl)imino)methyl)naphthalene-2-ol [SBL2] which were prepared via reflux condensations from their precursors. The ligands, SBL1 and SBL2 were reacted with the acetate (Cu and Mn), and sulphate (Fe) salts in molar ratio of 1:1:1 affording the complexes with various shades of colour distinct from the starting reagents. The melting points of the complexes ranged from 208 to 350 °C. The FT-IR spectrum of SBL1 and SBL2 presented a band at 1633cm-1 and 1669 cm-1 which moved to 1625-1642cm-1 in the complexes and was apportioned to an azomethine moiety. The electronic spectra of the [Cu(L1)(L2)], [Fe(L1)(L2)(H2O)2]H2O, and [Mn(L1)(L2)] are compatible with square planar, tetrahedral, and octahedral geometry. The compounds were found to exhibit one form of action or the other against all the screened microbes with [Mn(L1)(L2)]H2O] displaying the highest inhibitory zone of 15.5mm against Staphylococcus epidermidis, which is more effective compared to the positive control (streptomycin).The anti-fungiform study designated that the ligands and its complexes are highly active against Aspergillums flavus, fusarium sp. and Aspergillus niger with SBL2 ligand displaying the highest inhibitory zones of 25.0mm against Aspergillus niger.[Cu(L1)(L2)]complex also displayed the highest inhibitory zones of 17mm and 13mm against Aspergillus niger and Aspergillus flavus. The stereochemistry and electron distribution features of SBL and [M(L1)(L2)]complexes remained examined more by DFT evaluation. The result designated that the SBL and its complexes are soft molecules due to their high tendency of bioavailability and can be a better agent against bacteria. The compounds also showed a high electrophilic value which indicates strong electron acceptor.
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References
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