Synthesis, Characterization and Antimicrobial Properties of Metal-based Tosylamides
Keywords:
Bioactivity, Metal Complexes, Tosylamide, Synthesis, Antimicrobial PropertiesAbstract
As a group of pharmaceuticals, the metal complex of heterocyclic tosylamide derivatives is one of the most extensive classes in medicinal chemistry; its members are employed in the treatment of infections, diabetes, inflammation, and neurological diseases. This work explored the synthesis, characterisation, and antibacterial activity of tosylamide metal complexes. Further steps involved synthesising and recrystallising the ligand's Co (II) and Ni (II) complexes in suitable solvents. Melting point and thin layer chromatography were employed to ascertain the purity levels. To better understand the complexes and ligands, we used ESI-MS, FTIR, and NMR to get structural details. The fact that specific absorption bands in the infrared spectra of tosylamide derivatives moved to higher or lower wave numbers in the complexes proved that there was azomethine nitrogen coordinating with the metal ion. The produced ligand and its metal complexes were evaluated for their antimicrobial properties against several species of E. coli, Bacillus, Salmonella, Penicillium, and Candida. Some coordinated ligands shown even higher efficiency against these diseases, yet the ligand and its complexes were effective against the selected bacterial and fungal strains. In comparison to common antibacterial drugs like tetracycline and nystatin, the produced chemicals showed reduced sensitivity.
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