Histopathological Effects in Albino Rats Fed with Pleurotus ostreatus Cultivated on Composted Wood Dust Substrates
DOI:
https://doi.org/10.63561/jacsr.v3i1.1227Keywords:
Albino rats, Biosafety assessment, Composted substrates, Histopathology, Pleurotus ostreatusAbstract
.This study evaluated the histopathological effects of feeding albino rats with Pleurotus ostreatus cultivated on composted wood dust of Pycnanthus angolensis and Spondias mombin mixed with various animal dungs. Experimental rats were fed with mushroom-supplemented diets for twenty-one days, after which histopathological analyses were conducted on their liver, kidney, and intestine. The results revealed that most organs displayed normal architecture, with no signs of necrosis, haemorrhage, or inflammation. Mild histological alterations such as inflammatory cell infiltration and hepatocellular karyolysis were observed in some treatments, particularly those involving poultry droppings and sheep dung substrates. Rats fed with mushrooms from composted substrates showed significantly higher weight gain compared to controls, with the highest gain (13.67 g) recorded in the group fed with S. mombin and cow dung substrate. These findings indicate that P. ostreatus cultivated on composted wood dust substrates is non-toxic and nutritionally beneficial to experimental animals, suggesting its safety for human consumption.
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